Monodisperse LNPs - from Efficient Microfluidic Production and Loading to in Vitro Testing

Abstract excerpt

Carrier nanoparticles facilitate the encapsulation of drug or mRNA molecules thereby enhancing their bioavailability. Microfluidic mixers provide a unique environment for the precise and continuous generation of nanoparticles by antisolvent precipitation. A major challenge is to understand the influence of microfluidic channel designs and geometries on the continuous production of small, uniform lipid nanoparticle...

Topics

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• Coculture Techniques
• Drug Evaluation, Preclinical
• Lab-On-A-Chip Devices
• Liver
• Models, Biological
• Phenotype
• Rats
• RNA Interference and Gene Delivery

Identifiers and source

Literature Corpus work

057113f4-e07c-58d3-85da-a86dfdabf5a3

DOI

10.64898/2025.12.23.696212