Article

Endogenous retroelement activation is implicated in IFN-α production and anti-CCP autoantibody generation in early RA

2024-01-20

Abstract excerpt

<h4>Objectives</h4> Endogenous retroelements (EREs) stimulate type 1 interferon (IFN-I) production but have not been explored as potential interferonogenic triggers in Rheumatoid Arthritis (RA). We investigated ERE expression in early RA (eRA), a period where IFN-I is increased. <h4>Methods</h4> ERE expression in DMARD naïve eRA whole blood (LINE1; RT-PCR) and bulk synovial tissue (LTR5, LINE1, SINE; Nanostring) w...

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Literature Corpus work: 9ab78097-3cd2-5e78-a678-ec96aa592de6
DOI: 10.1101/2024.01.17.24301287

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