Article

Nonsynonymous A-to-I RNA editing contributes to burden of deleterious missense variants in healthy individuals

2018-11-05

Abstract excerpt

<h4>ABSTARCT</h4> Adenosine-to-inosine (A-to-I) RNA editing is a very common post-transcriptional modification that can lead to A-to-G changes at the RNA level and compensate for G-to-A genomic changes to a certain extent. It has been shown that each healthy individual can carry dozens of missense variants predicted to be severely deleterious. Why strongly detrimental variants are preserved in a population and no...

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Identifiers and source

Literature Corpus work: 9a8dc775-ace9-5946-9e8e-52b65b240206
DOI: 10.1101/462390

Open publication

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