Article

Regulation Flow Analysis discovers molecular mechanisms of action from large knowledge databases

2025-06-20

Abstract excerpt

Drug development is a long and expensive process, with only a small fraction of potential drugs being finally approved. The challenge of drug development is rooted in our limited understanding of biological systems and the disease processes that drugs are trying to modulate. We propose a novel method, called Regulation Flow Analysis (RFA), which is based on the principles of biological regulation, causal graphs, a...

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Literature Corpus work: 9a718438-bc44-5f4a-a6bc-ed9c0860ef88
DOI: 10.1101/2025.06.15.659785

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