Article

A Systems-Level Framework for Drug Discovery Identifies Csf1R As A Novel Anti-Epileptic Drug Target

2017-05-22

Abstract excerpt

<h4>ABSTRACT</h4> The identification of mechanistically novel drug targets is highly challenging, particularly for diseases of the central nervous system. To address this problem we developed and experimentally validated a new computational approach to drug target identification that combines gene-regulatory information with a causal reasoning framework (“causal reasoning analytical framework for target discovery...

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Literature Corpus work: 5643244d-dbf5-54f3-879e-c07519c0673f
DOI: 10.1101/140087

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