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Article

Drug2ways: Reasoning over causal paths in biological networks for drug discovery.

PLoS computational biology - 1 Dec 2020

Rivas-Barragan Daniel, Mubeen Sarah, Guim Bernat Francesc, Hofmann-Apitius Martin, Domingo-Fernández Daniel

Abstract excerpt

Elucidating the causal mechanisms responsible for disease can reveal potential therapeutic targets for pharmacological intervention and, accordingly, guide drug repositioning and discovery. In essence, the topology of a network can reveal the impact a drug candidate may have on a given biological state, leading the way for enhanced disease characterization and the design of advanced therapies. Network-based...

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Identifiers

PMID: 33264280
DOI: 10.1371/journal.pcbi.1008464
PMCID: PMC7735677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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