Article

VE-cadherin NOT-gated CD93 CAR T cells discriminate between AML and healthy endothelial cells

2026-03-11

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of B cell malignancies, but translation to acute myeloid leukemia (AML) has been hindered by on-target, off-tumor (OTOT) toxicity. In particular, endothelial cell (EC)-specific toxicity has limited clinical translation of promising leukemia stem cell-enriched targets such as CD93. Innovative strateg...

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Literature Corpus work: 9a547e3c-0c62-5c73-9ed1-cd2d1dfcd51d
DOI: 10.64898/2026.03.09.710630

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