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Article

Functional integration of acute myeloid leukemia into the vascular niche.

Leukemia - 1 Oct 2014

Cogle Christopher R, Goldman Devorah C, Madlambayan Gerard J, Leon Ronald P, Masri Azzah Al, Clark Hilary A, Asbaghi Steven A, Tyner Jeffrey W, Dunlap Jennifer, Fan Guang, Kovacsovics Tibor, Liu Qiuying, Meacham Amy, Hamlin Kimberly L, Hromas Robert A, Scott Edward W, Fleming William H

Abstract excerpt

Vascular endothelial cells are a critical component of the hematopoietic microenvironment that regulates blood cell production. Recent studies suggest the existence of functional cross-talk between hematologic malignancies and vascular endothelium. Here we show that human acute myeloid leukemia (AML) localizes to the vasculature in both patients and in a xenograft model. A significant number of vascular...

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Identifiers

PMID: 24637335
DOI: 10.1038/leu.2014.109
PMCID: PMC4167983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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