Back to search

Article

Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in <i>Mycobacterium tuberculosis</i>

2022-02-13

Abstract excerpt

<h4>ABSTRACT</h4> Despite the existence of well-characterized, canonical mutations that confer high-level drug resistance to Mycobacterium tuberculosis (Mtb), there is evidence that drug resistance mechanisms are more complex than simple acquisition of such mutations. Recent studies have shown that Mtb can acquire non-canonical resistance-associated mutations that confer survival advantages in the presence of ce...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9a0378ce-2254-5bc4-b857-2511decda8dc
DOI
10.1101/2022.02.13.480260
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in <i>Mycobacterium tuberculosis</i>DOI 10.1101/2022.02.13.480260
Loss of RNase J leads to multi-drug tolerance and accumulation of highly structured mRNA fragments in Mycobacterium tuberculosisSemantic proximity
Cell-wall synthesis and ribosome maturation are co-regulated by an RNA switch in <i>Mycobacterium tuberculosis</i>Semantic proximity
Small RNA Mcr11 regulates genes involved in the central metabolism of <i>Mycobacterium tuberculosis</i> and requires 3’ sequence along with the transcription factor AbmR for stable expressionSemantic proximity
Loss of the <i>PPE71-esxX-esxY-PPE38</i> locus drives adaptive transcriptional responses and hypervirulence of <i>Mycobacterium tuberculosis</i> Lineage 2Semantic proximity
Desiccation-induced DNA damage facilitates drug resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity
Evaluation of the role of <i>whiB6</i> and <i>kdpDE</i> in the dominant multidrug resistant clone <i>Mycobacterium tuberculosis</i> B0/W148Semantic proximity
A tRNA modification in <i>Mycobacterium tuberculosis</i> facilitates optimal intracellular growthSemantic proximity
Deciphering the transcriptomic landscape of pyrazinamide resistance in <i>Mycobacterium tuberculosis</i>Semantic proximity
Mycobacterial RNase E cleaves with a distinct sequence preference and controls the degradation rates of most <i>Mycolicibacterium smegmatis</i> mRNAsSemantic proximity
Incomplete transcripts dominate the <i>Mycobacterium tuberculosis</i> transcriptomeSemantic proximity
Long non-coding RNA molecules in tuberculosisSemantic proximity
PE/PPE proteins contribute to <i>Mycobacterium tuberculosis</i> drug resistanceSemantic proximity
Select a neighboring publication to make it the new centre.