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High resolution spatial transcriptomics decodes the microenvironmental determinants of response to Nr-CWS therapy in cervical precancerous lesions

2026-06-07

Abstract excerpt

<h4>SUMMARY</h4> Immunotherapy with Nocardia rubra cell wall skeleton (Nr-CWS) can clear human papillomavirus (HPV) and induce regression of cervical precancerous lesions, yet many patients do not respond. The cellular and molecular basis for this heterogeneous clinical outcome remains unknown. Using high-resolution spatial transcriptomics, we profiled squamous intraepithelial lesions (SIL) from patients stratifi...

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Literature Corpus work
99c5a7e4-2493-5bf1-a395-c36f6ce6464c
DOI
10.64898/2026.06.02.729727
Open publication

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High resolution spatial transcriptomics decodes the microenvironmental determinants of response to Nr-CWS therapy in cervical precancerous lesionsDOI 10.64898/2026.06.02.729727
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