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BRD4 PROTAC Degrader ARV-825 Inhibits T-Cell Acute Lymphoblastic Leukemia by Targeting 'Undruggable' Myc-pathway Genes

2020-12-17

Abstract excerpt

<title>Abstract</title> <p>BackgroundT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease with a high risk of induction failure and poor outcomes, with relapse due to drug resistance. Targeting bromodomains and extra-terminal (BET) protein inhibitors are promising anti-cancer agents, and ARV-825, comprising a BET inhibitor conjugated with cereblon, was recently shown to attenuate the growth of mul...

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Literature Corpus work: 72bcaa3b-4622-5b76-8a1a-5d814af1e6d2
DOI: 10.21203/rs.3.rs-129258/v1

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