Article

Role of PARylation and PTEN Mutation on PARP and PARG Inhibitor Efficacy on Glioblastoma

2020-07-01

Abstract excerpt

Glioblastoma (GBM) is the most aggressive primary adult brain tumor, with a median survival of approximately 15 months. Despite novel therapeutic approaches, median survival has remained largely unchanged since the standard of care therapy for GBM was established nearly 15 years ago. Phosphatase and tensin homolog (PTEN) is a prognostic biomarker of GBM. PTEN mutation is associated with defects in homologous recom...

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Literature Corpus work: 997ae3ae-ab27-5143-8386-30579eed5a7f
DOI: 10.1101/2020.06.30.180216

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