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Article

PARP inhibitors in gastric cancer: beacon of hope

24 Jun 2021

Abstract excerpt

Defects in the DNA damage response (DDR) can lead to genome instability, producing mutations or aberrations that promote the development and progression of cancer. But it also confers such cells vulnerable to cell death when they inhibit DNA damage repair. Poly (ADP-ribose) polymerase (PARP) plays a central role in many cellular processes, including DNA repair, replication, and transcription. PARP induces the...

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PMID: 34167572
DOI: 10.1186/s13046-021-02005-6

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