Article

Data-Driven Symbolic Higher-Order Epistasis Discovery with Kolmogorov-Arnold Networks

2025-11-04

Abstract excerpt

Many human diseases are polygenic conditions that arise from a complex interplay of interactions between multiple genes at different loci, but currently most Genome-Wide Association Studies (GWAS) largely only consider the main additive effects of single nucleotide polymorphisms (SNPs), resulting in a missing heritability problem in some complex traits. Identifying non-additive interactions, or epistasis, at a hig...

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Literature Corpus work: 99611928-40f7-58ad-a4fa-821162d0640c
DOI: 10.1101/2025.10.31.685894

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