Article

Rescuing AAV gene transfer from antibody neutralization with an IgG-degrading enzyme

2020-05-14

Abstract excerpt

Pre-existing humoral immunity to recombinant adeno-associated viral (AAV) vectors restricts the treatable patient population and efficacy of human gene therapies. Approaches to clear neutralizing antibodies (NAbs), such as plasmapheresis and immunosuppression are either ineffective or cause undesirable side effects. Here, we describe a clinically relevant strategy to rapidly and transiently degrade NAbs prior to A...

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Identifiers and source

Literature Corpus work: 7ec265a2-aafc-5ba7-ac9c-11fad7a520ea
DOI: 10.1101/2020.05.12.092122

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