Article

Epigenetic in Obstructive Sleep Apnea: miR-145-5p targets DNMT3A and regulates DNA methylation homeostasis in upper airway muscle

2022-12-14

Abstract excerpt

<title>Abstract</title><p>Background Epigenetic modifications, especially DNA methylation and post-transcriptional miRNA-mediated regulation, are closely related to the occurrence and development of obstructive sleep apnea (OSA). Our previous study found that reduced expression of miR-145-5p may be a serological early warning marker for OSA diagnosis alone, but the underlying mechanism is unknown. Objectives To ex...

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Literature Corpus work: 9941f571-9331-5093-8815-2a69686a10d8
DOI: 10.21203/rs.3.rs-2360325/v1

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