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RNA-Sequencing And Mass-Spectrometry Proteomic Time-Series Analysis of T-Cell Differentiation Identified Multiple Splice Variants Models That Predicted Validated Protein Biomarkers In Inflammatory Diseases

2021-09-17

Abstract excerpt

<h4>Background: </h4> Profiling of mRNA expression is an important method to identify biomarkers but complicated by limited correlations between mRNA expression and protein abundance. We hypothesized that these correlations could be improved by mathematical models based on measuring splice variants and time delay in protein translation. <h4>Methods: </h4> We characterized time-series of primary human naïve CD4+ T...

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Literature Corpus work: 98e3fa58-954b-5d6c-9251-310df49bb7ab
DOI: 10.21203/rs.3.rs-880591/v1

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