Article

A validated strategy to infer protein biomarkers from RNA-Seq by combining multiple mRNA splice variants and time-delay

2019-04-04

Abstract excerpt

<h4>Background</h4> Profiling of mRNA expression is an important method to identify biomarkers but complicated by limited correlations between mRNA expression and protein abundance. We hypothesised that these correlations could be improved by mathematical models based on measuring splice variants and time delay in protein translation. <h4>Methods</h4> We characterised time-series of primary human naïve CD4 + T...

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Literature Corpus work: 98a65bb1-e4ca-592c-90d9-a46f7141cb24
DOI: 10.1101/599373

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