Article

Biophysical studies of TIMP-1

1995-01-01

Abstract excerpt

This study had two aspects. The first was the production and purification of TIMP-l. The second was a series of biophysical studies of TIMP-l and a TIMP-l derived peptide. A monoclonal antibody affinity column was developed and used to purifY large quantities of human TIMP-l for further experiments. Two E.coli expression systems were studied to determine whether they would be suitable for large scale production of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 98e3cf9e-7f7d-5235-874f-72355d79b5ae
DOI: 10.21954/ou.ro.0000e0ca

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Biophysical studies of TIMP-1DOI 10.21954/ou.ro.0000e0caRead

The TIMP protein family: diverse roles in pathophysiologySemantic proximity Read

The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment.Semantic proximity Read

The Specificity of TIMP-2 for Matrix Metalloproteinases Can Be Modified by Single Amino Acid MutationsSemantic proximity Read

Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide ExtensionSemantic proximity Read

The isolated N-terminal domains of TIMP-1 and TIMP-3 are insufficient for ADAM10 inhibition.Semantic proximity Read

Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancerSemantic proximity Read

Whole Organism Profiling of the Timp Gene FamilySemantic proximity Read

Total conversion of tissue inhibitor of metalloproteinase (TIMP) for specific metalloproteinase targeting: fine-tuning TIMP-4 for optimal inhibition of tumor necrosis factor-{alpha}-converting enzyme.Semantic proximity Read

Establishment of Structure-Function Relationship of Tissue Inhibitor of Metalloproteinase-1 for Its Interaction with CD63: Implication for Cancer TherapySemantic proximity Read

Biology of Tissue Inhibitor of Metalloproteinase 3 (TIMP3), and Its Therapeutic Implications in Cardiovascular PathologySemantic proximity Read

Tissue Inhibitor of Metalloproteinases-4. The road less traveledSemantic proximity Read

Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).Semantic proximity Read