Article

HistoGWAS: An AI Framework for Automated and Interpretable Genetic Analysis of Tissue Phenotypes

2024-06-12

Abstract excerpt

Understanding how genetic variation affects tissue structure and function is crucial for deciphering disease mechanisms, yet comprehensive methods for genetic analysis of tissue histology are lacking. We address this gap with HistoGWAS, a framework integrating AI tools for representation learning and image generation with fast variance component models to enable scalable and interpretable genome-wide association s...

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Literature Corpus work: 98b993d5-61ec-5dfa-9555-393b1f381d89
DOI: 10.1101/2024.06.09.597752

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