Article

VADEr: Vision Transformer-Inspired Framework for Polygenic Risk Reveals Underlying Genetic Heterogeneity in Prostate Cancer

2025-05-18

Abstract excerpt

Polygenic risk scores (PRSs) serve as quantitative metrics of genetic liability for various conditions. Traditionally calculated as an effect size weighted genotype summation, this formulation assumes conditional feature independence and overlooks the potential for complex interactions among genetic variants. Transformers, a class of deep learning architectures known for capturing dependencies between features, ha...

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Literature Corpus work: 66fb0a1b-07d7-541d-8375-cf5df076e0ef
DOI: 10.1101/2025.05.16.25327672

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