Article

Somatic Mutations in Clonally Expanded T-lymphocytes in Patients with Chronic Graft-Versus-Host Disease

2019-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Graft-versus-host-disease (GvHD) is the main complication of allogeneic hematopoietic stem cell transplantation. GvHD patients have aberrant T cell expansions, which are thought to drive pathological immune activation. Here we report mechanistic insights that somatic mutations may account for persistent clonal T cell expansions in chronic GvHD (cGvHD). In an index patient suffering from cGVHD, w...

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Literature Corpus work: 98ae7175-977b-5e6c-888a-cd7118ec6739
DOI: 10.1101/747196

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