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How Aging Causes Osteoarthritis: An Evolutionary Physiology Perspective

2024-09-16

Abstract excerpt

Late-life diseases result from the poorly understood process of senescence (aging), that is largely genetically determined. According to a recently proposed evolutionary physiology-based account, the multifactorial model, senescence is largely caused by evolved but non-adaptive programmatic mechanisms specified by the wild-type (i.e. normal) genome. These act together with disruptions to wild-type function (due e....

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Literature Corpus work
98ae21a7-fa2c-573a-b77f-5f902ec62e32
DOI
10.20944/preprints202409.1180.v1
Open publication

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