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Article

Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity

2025-06-27

Abstract excerpt

<title>Abstract</title> <p>(70 words) We evaluated the impact of spaceflight on a microphysiologic model of calcium oxalate (CaOx) kidney stone disease. Proximal tubule epithelial cells cultured as confluent microtubules were exposed to CaOx crystals with or without potassium citrate (a potential countermeasure) to determine impact on gene expression. Nine genes were differentially expressed in response to CaOx c...

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Literature Corpus work
9895127d-d908-56e2-ad78-a73959961dd9
DOI
10.21203/rs.3.rs-6883199/v1
Open publication

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