Article
A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models.
Cancer research - 1 Aug 2013
Zhang Xiaomei, Claerhout Sofie, Prat Aleix, Dobrolecki Lacey E, Petrovic Ivana, Lai Qing, Landis Melissa D, Wiechmann Lisa, Schiff Rachel, Giuliano Mario, Wong Helen, Fuqua Suzanne W, Contreras Alejandro, Gutierrez Carolina, Huang Jian, Mao Sufeng, Pavlick Anne C, Froehlich Amber M, Wu Meng-Fen, Tsimelzon Anna, Hilsenbeck Susan G, Chen Edward S, Zuloaga Pavel, Shaw Chad A, Rimawi Mothaffar F, Perou Charles M, Mills Gordon B, Chang Jenny C, Lewis Michael T
Abstract excerpt
Breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. To overcome these limitations, we propagated a cohort of human breast tumors grown in the epithelium-free mammary fat pad of severe combined immunodeficient (SCID)/Beige and nonobese diabetic (NOD)/SCID/IL-2γ-receptor...
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