Article
Identification and characterization of a rare variant in apolipoprotein A-IV, p.(V336M), and evaluation of HDL functionality in a Greek cohort with extreme HDL cholesterol levels.
Archives of biochemistry and biophysics - 15 Dec 2020
Chroni Angeliki, Rallidis Loukianos, Vassou Despoina, Gkolfinopoulou Christina, Papakosta Paraskevi, Zervou Maria I, Goulielmos George N, Kiouri Estela, Pappa Danae, Eliopoulos Elias, Kardassis Dimitris
Abstract excerpt
High-Density Lipoprotein cholesterol (HDL-C) levels do not correlate well with Coronary Artery Disease (CAD) risk, while HDL functionality affects atherogenesis and is a better prognostic marker for CAD. Often, the extreme HDL-C levels have a multigenic origin. Here, we searched for single-nucleotide polymorphisms (SNPs) in ten genes of HDL metabolism in a Greek cohort with very low (<10th percentile, n = 13) or...
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