Article

Ruxolitinib partially reverses functional NK cell deficiency in patients with <i>STAT1</i> gain-of-function mutations

2017-06-28

Abstract excerpt

<h4>Background</h4> Natural Killer (NK) cells are critical innate effector cells whose development is dependent on the JAK-STAT pathway. NK deficiency can result in severe or refractory viral infections. Patients with Signal Transducer and Activator of Transcription (STAT)1 gain of function (GOF) mutations have increased viral susceptibility. <h4>Objective</h4> We sought to investigate NK cell function in STAT1...

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Literature Corpus work: 986fa333-ffed-5d62-a1ee-364846dad05f
DOI: 10.1101/157271

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