Development and clinical validation of a cross-sex translator of ECG drug responses

Abstract excerpt

Sex differences in cardiac electrophysiology are a crucial factor affecting arrhythmia risk and treatment responses. It is well-documented that females are at a higher risk of drug-induced Torsade de Pointes and sudden cardiac death, largely due to longer QTc intervals compared to males. However, the underrepresentation of females in both basic and clinical research introduces biases that hinder our understanding...

Topics

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• Alleles
• Arrhythmias, Cardiac
• Cardiac electrophysiology and arrhythmias
• Cardiac Pacing, Artificial
• Death, Sudden, Cardiac
• Defibrillators, Implantable
• Ion channel regulation and function
• Long QT Syndrome

Identifiers and source

Literature Corpus work

dcbd69c4-511d-5d0a-a50c-d97883fdab80

DOI

10.1101/2024.12.27.24319698