Article

Evaluating predictive biomarkers for a binary outcome with linear versus logistic regression – Practical recommendations for the choice of the model

2018-06-14

Abstract excerpt

A predictive biomarker can forecast whether a patient benefits from a specific treatment under study. To establish predictiveness of a biomarker, a statistical interaction between the biomarker status and the treatment group concerning the clinical outcome needs to be shown. In clinical trials looking at a binary outcome, linear or logistic regression models may be used to evaluate the interaction, but the effects...

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Literature Corpus work: 982d2766-7328-58ce-a0fc-11b01e7a1e41
DOI: 10.1101/347096

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