Article

Favoring the hierarchical constraint in penalized survival models for randomized trials in precision medicine

2022-07-06

Abstract excerpt

<h4>Background: </h4> The research of biomarker-treatment interactions is commonly investigated in randomized clinical trials (RCT) for improving medicine precision. The hierarchical interaction constraint states that an interaction should only be in a model if its main effects are also in the model. However, this constraint is not guaranteed in the different penalized statistical approaches used for high-dimensio...

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Literature Corpus work: e587d6f8-cd3e-59c9-9ea1-697bea17b511
DOI: 10.21203/rs.3.rs-1704744/v1

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