Article

The <i>Escherichia coli</i> TolC efflux pump protein is immunogenic and elicits protective antibodies

2023-10-09

Abstract excerpt

Antimicrobial resistance is an increasing worldwide public health burden that threatens to make the existent antimicrobials obsolete. Among the mechanisms of antimicrobial resistance is the overexpression of efflux pumps, such as the AcrA–AcrB–TolC which extrude diverse compounds, reducing the intracellular concentration of antimicrobials. TolC is the outer membrane protein of this pump and has recently gained att...

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Literature Corpus work: 97ea82a5-5eb4-5d5e-9101-5542a6a3e03b
DOI: 10.1101/2023.10.09.559948

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