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Article

High-Throughput Methods for Variant Functional Assessment in Cardiac Disease.

Circulation. Genomic and precision medicine - 1 Feb 2026

Dolder Richard E, Friedman Clayton E, Loiben Alexander M, Yang Kai-Chun, Glazer Andrew M

Abstract excerpt

In vitro functional modeling of genetic variants has revolutionized our understanding of which variants can cause cardiac disorders, providing insights into their molecular underpinnings. This review provides an overview of high-throughput methods used for the functional assessment of variants implicated in inherited cardiac diseases. Advances in gene-editing technology now enable the efficient generation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41603018
DOI: 10.1161/CIRCGEN.125.005239
PMCID: PMC12857764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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