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The Genetic Revolution in Cardiometabolic Disease: A Review of Novel RNA and Gene‐Editing Therapies Targeting APOC3, ANGPTL3, and Lp(a)

2025-11-13

Abstract excerpt

<h4>Background: </h4> /Objectives: Despite the success of statin and PCSK9 inhibitor therapies, significant residual cardiovascular risk persists, driven by atherogenic triglyceride-rich lipoproteins (TRLs) and the independent, causal risk factor, lipoprotein(a) [Lp(a)]. This review aims to elucidate the pathophysiology of three key genetic drivers of this risk—Apolipoprotein C-III (APOC3), Angiopoietin-like prote...

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Literature Corpus work
ca0dd4ef-e0ed-53e5-997a-c252573851a0
DOI
10.20944/preprints202511.0942.v1
Open publication

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