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Long noncoding RNAs in familial hypercholesterolemia: biomarkers, therapeutics, and AI in precision medicine

21 May 2025

Abstract excerpt

Long noncoding RNAs (lncRNAs) have emerged as critical regulators of lipid metabolism, playing pivotal roles in cholesterol biosynthesis, transport, and efflux. Familial Hypercholesterolemia (FH), a genetic disorder characterized by excessive low-density lipoprotein cholesterol (LDL-C) levels, remains a significant contributor to premature cardiovascular disease (CVD). Traditional diagnostic methods, including...

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PMID: 40399983
DOI: 10.1186/s12944-025-02605-7

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