Article

Distinct muscle regenerative capacity of human induced pluripotent stem cell-derived mesenchymal stromal cells in Ullrich congenital muscular dystrophy model mice

2024-08-23

Abstract excerpt

<title>Abstract</title> Background Ullrich congenital muscular dystrophy (UCMD) is caused by a deficiency in type 6 collagen (COL6) due to mutations in <italic>COL6A1</italic>, <italic>COL6A2</italic>, or <italic>COL6A3</italic>. COL6 deficiency alters the extracellular matrix structure and biomechanical properties, leading to mitochondrial defects and impaired muscle regeneration. Therefore, mesenchymal stro...

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Literature Corpus work: 96d8c42f-c610-5697-bdbb-da6b0755ffc0
DOI: 10.21203/rs.3.rs-4721677/v1

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