Article

PML mutants resistant to arsenic induced degradation fail to generate the appropriate SUMO and ubiquitin signals required for RNF4 and p97 recruitment

2023-01-17

Abstract excerpt

<h4>ABSTRACT</h4> Arsenic is an effective treatment for Acute Promyelocytic Leukaemia as it induces degradation of the Promyelocytic Leukaemia (PML) – retinoic acid receptor alpha (RARA) oncogenic fusion protein. Some patients relapse with arsenic resistant disease because of missense mutations in PML. To determine the mechanistic basis for arsenic resistance we reconstituted PML-/- cells with YFP fusions of wild...

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Literature Corpus work: 969eb349-6dae-507b-8c43-ba757a27f971
DOI: 10.1101/2023.01.15.524136

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