Article

Patterns of selection against centrosome amplification in human cell lines

2020-01-25

Abstract excerpt

The presence of extra centrioles, or centrosome amplification, is a hallmark of cancer cells. Centriole numbers in cancer cell populations appear to be at an equilibrium maintained by centriole overproduction and selection, reminiscent of mutation-selection balance. It is not known if the interaction between centriole overproduction and selection can quantitatively explain the intra- and inter-population heterogen...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 96194d02-3a4b-57c7-82b0-acded4be26e1
DOI: 10.1101/2020.01.24.918615

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Patterns of selection against centrosome amplification in human cell linesDOI 10.1101/2020.01.24.918615Read

Patterns of selection against centrosome amplification in human cell lines.Semantic proximity Read

Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregationSemantic proximity Read

Using Cell Culture Models of Centrosome Amplification to Study Centrosome Clustering in Cancer.Semantic proximity Read

A Markov chain for numerical chromosomal instability in clonally expanding populations.Semantic proximity Read

Show me your license, please: deregulation of centriole duplication mechanisms that promote amplificationSemantic proximity Read

A catalog of numerical centrosome defects in epithelial ovarian cancersSemantic proximity Read

Uncoordinated centrosome cycle underlies the instability of non-diploid somatic cells in mammalsSemantic proximity Read

A theory of evolutionary dynamics on any complex population structure reveals stem cell niche architecture as a spatial suppressor of selection.Semantic proximity Read