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Article

Patterns of selection against centrosome amplification in human cell lines.

PLoS computational biology - 1 May 2021

Dias Louro Marco António, Bettencourt-Dias Mónica, Bank Claudia

Abstract excerpt

The presence of extra centrioles, termed centrosome amplification, is a hallmark of cancer. The distribution of centriole numbers within a cancer cell population appears to be at an equilibrium maintained by centriole overproduction and selection, reminiscent of mutation-selection balance. It is unknown to date if the interaction between centriole overproduction and selection can quantitatively explain the intra-...

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Identifiers

PMID: 33979341
DOI: 10.1371/journal.pcbi.1008765
PMCID: PMC8143425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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