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Exploring pangenomic diversity and CRISPR-Cas evasion potential in jumbo phages: a comparative genomics study.

Microbiology spectrum - 3 Oct 2024

Magar Sharayu, Kolte Vaishnavi, Sharma Gaurav, Govindarajan Sutharsan

Abstract excerpt

Jumbo phages are characterized by their remarkably large-sized genome and unique life cycles. Jumbo phages belonging to Chimalliviridae family protect the replicating phage DNA from host immune systems like CRISPR-Cas and restriction-modification system through a phage nucleus structure. Several recent studies have provided new insights into jumbo phage infection biology, but the pan-genome diversity of jumbo...

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Identifiers

PMID: 39264185
DOI: 10.1128/spectrum.04200-23
PMCID: PMC11448039

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