Article

Greater breadth of vaccine-induced immunity in females than males is mediated by increased antibody diversity in germinal center B cells

2022-06-01

Abstract excerpt

Inactivated influenza vaccines induce greater antibody responses in females than males among both humans and mice. To test the breadth of protection, we used recombinant mouse-adapted A/California/2009 (maA/Cal/09) H1N1 viruses containing mutations at one (1M), two (2M), or three (3M) antigenic sites, in addition to a virus containing the 1M mutation and a substitution of the Ca2 antigenic site (Sub) with one deri...

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Literature Corpus work: 95795196-5c31-54b0-8be4-3b168e194124
DOI: 10.1101/2022.05.31.494237

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