Article

Decoupled calcium homeostasis and signaling associated with cytoskeletal instability in YWHAG R132C induced pluripotent stem cell-derived cortical neurons

2026-04-03

Abstract excerpt

<h4>ABSTRACT</h4> YWHAG Syndrome (Developmental and Epileptic Encephalopathy 56, DEE56) is an ultra- rare childhood epilepsy associated with neurodevelopmental delays, with no therapeutic intervention available. Multiple de novo mutations in the YWHAG gene, encoding for the 14-3-3γ protein, have been identified as causative for YWHAG Syndrome. 14-3-3γ interacts with various targets, including major neurodevelop...

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Literature Corpus work: 9550f917-eae5-56b4-869a-e042faa8252e
DOI: 10.64898/2026.04.01.715876

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