GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons.

doi:10.1096/fj.202001113R

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Article

GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2020

Akamine Satoshi, Okuzono Sayaka, Yamamoto Hiroyuki, Setoyama Daiki, Sagata Noriaki, Ohgidani Masahiro, Kato Takahiro A, Ishitani Tohru, Kato Hiroki, Masuda Keiji, Matsushita Yuki, Ono Hiroaki, Ishizaki Yoshito, Sanefuji Masafumi, Saitsu Hirotomo, Matsumoto Naomichi, Kang Dongchon, Kanba Shigenobu, Nakabeppu Yusaku, Sakai Yasunari, Ohga Shouichi

Abstract excerpt

Developmental and epileptic encephalopathy (DEE) represents a group of neurodevelopmental disorders characterized by infantile-onset intractable seizures and unfavorable prognosis of psychomotor development. To date, hundreds of genes have been linked to the onset of DEE. GNAO1 is a DEE-associated gene encoding the alpha-O1 subunit of guanine nucleotide-binding protein (GαO ). Despite the increasing number of...

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PMID: 33107105
DOI: 10.1096/fj.202001113R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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