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Levels of DNA accessibility in human sperm vary across individuals with differing reproductive parameters

2024-06-27

Abstract excerpt

Mammalian sperm DNA is packaged in a much denser form than in somatic cells, protecting the DNA from damage and reducing the size of the nucleus to improve passage towards the oocyte. While defective sperm DNA packaging correlates with reduced fertilization rates and impaired pre-implantation embryonic development, these defects are not currently examined in standard semen analysis. Here, we adapted NicE-view, an...

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Identifiers and source

Literature Corpus work
94cc260a-f543-54ee-b3dd-d31ecef6f25c
DOI
10.1101/2024.06.27.600938
Open publication

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Levels of DNA accessibility in human sperm vary across individuals with differing reproductive parametersDOI 10.1101/2024.06.27.600938
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