Article

Metagenome-wide measurement of protein synthesis in the human fecal microbiota using MetaRibo-Seq

2018-12-07

Abstract excerpt

The healthy human fecal microbiota is too diverse to comprehensively study with the current throughput of proteomic methods. Shotgun sequencing technologies allow for much more comprehensive profiling. Here, we develop and apply MetaRibo-Seq, a method for simultaneous ribosome profiling of multiple taxa within a complex bacterial community. This approach captures taxonomic diversity in fecal samples. As expected,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94bc92f0-905c-5b18-98ed-f8bddaa0230e
DOI: 10.1101/482430

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metagenome-wide measurement of protein synthesis in the human fecal microbiota using MetaRibo-SeqDOI 10.1101/482430Read

A Multi-Omics Processing Pipeline (MOPP) for Extracting Taxonomic and Functional Insights from Metaribosome Profiling (metaRibo-Seq) dataSemantic proximity Read

Metaproteomics as a tool for studying the protein landscape of human-gut bacterial speciesSemantic proximity Read

A robust metatranscriptomic technology for population-scale studies of diet, gut microbiome, and human healthSemantic proximity Read

Phenotypic heterogeneity in the human gut microbiome revealed by subspecies-resolution single-cell transcriptomicsSemantic proximity Read

Relating the metatranscriptome and metagenome of the human gutSemantic proximity Read

Integration of absolute multi-omics reveals dynamic protein-to-RNA ratios and metabolic interplay within mixed-domain microbiomes.Semantic proximity Read

A compilation of fecal microbiome shotgun metagenomics from hospitalized patients undergoing hematopoietic cell transplantationSemantic proximity Read

Comparative Metatranscriptomics of Periodontitis Supports a Common Polymicrobial Shift in Metabolic Function and Identifies Novel Putative Disease-Associated ncRNAsSemantic proximity Read

Comparative metatranscriptomics of periodontitis supports a common polymicrobial shift in metabolic function and identifies novel putative disease-associated ncRNAsSemantic proximity Read

Metaproteomics of colonic microbiota unveils discrete protein functions among colitic mice and control groupsSemantic proximity Read

Comprehensive Cross-Domain Taxonomic Classification of Microbiotas using Partitioned Amplification Multiplexed Amplicon Sequencing (PAMA-seq)Semantic proximity Read

Expanding the human metaproteome: enhancing small open reading frame (smORF) prediction and ultra-deep detection of smORF-encoded proteins in the gut microbiomeSemantic proximity Read