Article

Phenotypic heterogeneity in the human gut microbiome revealed by subspecies-resolution single-cell transcriptomics

2026-07-31

Abstract excerpt

Most of our knowledge about bacterial functional roles in microbiomes comes from bulk measurements. Yet microbial communities are complex ecosystems in which functionally distinct bacterial subpopulations with unique transcriptional states emerge across environmental niches and from interactions with other community members. Such heterogeneous transcriptional states are inherently missed by bulk measurements. To a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52794ce1-d419-53a6-be85-a49b1d985536
DOI: 10.64898/2026.07.30.741866

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phenotypic heterogeneity in the human gut microbiome revealed by subspecies-resolution single-cell transcriptomicsDOI 10.64898/2026.07.30.741866Read

Revealing within-species diversity in uncultured human gut bacteria with single-cell long-read sequencingSemantic proximity Read

Single‐microbe RNA sequencing uncovers unexplored specialized metabolic functions of keystone species in the human gutSemantic proximity Read

Relating the metatranscriptome and metagenome of the human gutSemantic proximity Read

Metagenomics and Single-Cell Omics Data Analysis for Human Microbiome Research.Semantic proximity Read

Subspecies in the global human gut microbiome.Semantic proximity Read

Bacterial single-cell transcriptomics: Recent technical advances and future applications in dentistrySemantic proximity Read

Main Manuscript for Microbiome single cell atlases generated with a benchtop instrumentSemantic proximity Read

Functional and Genomic Variation between Human-Derived Isolates of Lachnospiraceae Reveals Inter- and Intra-Species Diversity.Semantic proximity Read

Dissecting the human microbiome with single-cell genomicsSemantic proximity Read

Proteobacteria drive significant functional variability in the human gut microbiomeSemantic proximity Read

Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolutionSemantic proximity Read

Metagenome-wide measurement of protein synthesis in the human fecal microbiota using MetaRibo-SeqSemantic proximity Read