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Article

Integration of absolute multi-omics reveals dynamic protein-to-RNA ratios and metabolic interplay within mixed-domain microbiomes.

Nature communications - 18 Sept 2020

Delogu F, Kunath B J, Evans P N, Arntzen M Ø, Hvidsten T R, Pope P B

Abstract excerpt

While the field of microbiology has adapted to the study of complex microbiomes via modern meta-omics techniques, we have not updated our basic knowledge regarding the quantitative levels of DNA, RNA and protein molecules within a microbial cell, which ultimately control cellular function. Here we report the temporal measurements of absolute RNA and protein levels per gene within a mixed bacterial-archaeal...

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Identifiers

PMID: 32948758
DOI: 10.1038/s41467-020-18543-0
PMCID: PMC7501288

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