Article

From autophagy to clinical limb Salvage: Applying UCMSC Therapy from Experimental Ischemia to CLTI Patients

2026-08-24

Abstract excerpt

<title>Abstract</title> <p>Background : Chronic limb-threatening ischemia (CLTI) involves not only macrovascular arterial obstruction but also persistent metabolic stress and cellular dysfunction within ischemic tissue. Umbilical cord-derived mesenchymal stromal cells (UCMSCs) have pleiotropic regenerative properties, although the molecular pathways potentially contributing to recovery from limb ischemia remain i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94b57cfd-1883-58f9-9639-36c7798165b8
DOI: 10.21203/rs.3.rs-9718759/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

From autophagy to clinical limb Salvage: Applying UCMSC Therapy from Experimental Ischemia to CLTI PatientsDOI 10.21203/rs.3.rs-9718759/v1Read

Pro-inflammatory macrophages impair skeletal muscle regeneration in ischemic-damaged limbs by inducing precocious differentiation of satellite cellsSemantic proximity Read

Analyses of the pericyte transcriptome in ischemic skeletal musclesSemantic proximity Read

Intramuscular Adipose Tissue Accumulation is a Key Determinant of Limb Function in Peripheral Artery DiseaseSemantic proximity Read

Preclinical Evaluation of Bone Marrow Mesenchymal Stem Cells Overexpressing MicroRNA-126 to Treat Critical Limb IschemiaSemantic proximity Read

Noncoding RNAs in Critical Limb IschemiaSemantic proximity Read

Human Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hind Limb Ischemia by Promoting Angiogenesis in MiceSemantic proximity Read

Vascular regeneration and skeletal muscle repair induced by long-term exposure to SDF-1α derived from engineered mesenchymal stem cells after hindlimb ischemiaSemantic proximity Read

The role of therapeutic MicroRNA in arteriogenesis process in limb ischemia: A systematic reviewSemantic proximity Read

Mesenchymal Stromal Cell Transplantation Ameliorates Fibrosis and Dysregulated microRNA Signature Associated with Ischaemic Skeletal Muscle Damage.Semantic proximity Read

MicroRNA-30b Is Both Necessary and Sufficient for Interleukin-21 Receptor-Mediated Angiogenesis in Experimental Peripheral Arterial DiseaseSemantic proximity Read

Myeloid Drp1 Deficiency Limits Revascularization in Ischemic Muscles via Inflammatory Macrophage Polarization and Metabolic ReprogramingSemantic proximity Read

miR-1, miR-133a, and miR-29b and Skeletal Muscle Fibrosis in Chronic Limb-Threatening Ischaemia.Semantic proximity Read