Back to search

Article

Comparative Transcriptomics and Genomics from Continuous Axenic Media Growth Identifies <i>Coxiella burnetii</i> Intracellular Survival Strategies

2023-02-06

Abstract excerpt

Coxiella burnetii (Cb) is an obligate intracellular pathogen in nature and the causative agent of acute Q fever as well as chronic diseases. In an effort to identify genes and proteins crucial to their normal intracellular growth lifestyle, we applied a “Reverse evolution” approach where the avirulent Nine Mile Phase II strain of Cb was grown for 67 passages in chemically defined ACCM-D media and gene expression p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
946f2f08-6bac-5bee-ac70-42b4d1b4c6a7
DOI
10.1101/2023.02.06.527305
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Comparative Transcriptomics and Genomics from Continuous Axenic Media Growth Identifies <i>Coxiella burnetii</i> Intracellular Survival StrategiesDOI 10.1101/2023.02.06.527305
Host cell-free growth of the Q fever bacterium <i>Coxiella burnetii</i>Semantic proximity
Stepwise assembly of virulence-associated traits in the intracellular pathogen <i>Coxiella burnetii</i>Semantic proximity
Use of Axenic Culture Tools to Study Coxiella burnetiiSemantic proximity
Life on the Outside: The Rescue of Coxiella burnetii from Its Host CellSemantic proximity
Temporal Analysis of <i>Coxiella burnetii</i> Morphological DifferentiationSemantic proximity
Right on Q: Genetics begin to Unravel <i>Coxiella Burnetii</i> host cell InteractionsSemantic proximity
From neglected to dissected: How technological advances are leading the way to the study of Coxiella burnetii pathogenesis.Semantic proximity
Isolation from Animal Tissue and Genetic Transformation of Coxiella burnetii Are Facilitated by an Improved Axenic Growth MediumSemantic proximity
<i>Coxiella burnetii</i> establishes a small cell variant (SCV)-like persistent form to survive adverse intracellular conditionsSemantic proximity
Genetic mechanisms of Coxiella burnetii lipopolysaccharide phase variation.Semantic proximity
Coxiella burnetii: A Pathogenic Intracellular AcidophileSemantic proximity
Genomic Changes During the Evolution of the <i>Coxiella</i> Genus Along the Parasitism-Mutualism ContinuumSemantic proximity
Select a neighboring publication to make it the new centre.