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Craniofacial chondrogenesis in organoids from human stem cell-derived neural crest cells

28 Mar 2024

Abstract excerpt

Knowledge of cell signaling pathways that drive human neural crest differentiation into craniofacial chondrocytes is incomplete, yet essential for using stem cells to regenerate craniomaxillofacial structures. To accelerate translational progress, we developed a differentiation protocol that generated self-organizing craniofacial cartilage organoids from human embryonic stem cell-derived neural crest stem cells....

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PMID: 38623327
DOI: 10.1016/j.isci.2024.109585

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