Article

Structure adaptation in Omicron SARS-CoV-2/hACE2: Biophysical origins of evolutionary driving forces

2022-12-21

Abstract excerpt

Since its emergence, the Covid19 pandemic has been sustained by a series of transmission waves initiated by new variants of the SARS-CoV-2 virus. Some of these arise with higher transmissivity and/or increased disease severity. Here we use molecular dynamics simulations to examine the modulation of the fundamental interactions between the receptor binding domain (RBD) of the spike glycoprotein and the host cell re...

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Literature Corpus work: 93fbf27c-0f79-56eb-84c2-3414fb3cc17e
DOI: 10.1101/2022.12.20.521221

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